OPTIMI: Early Prediction and Prevention of Depression

Institute for Response-Genetics, Departement of Psychiatry (KPPP)

Psychiatric Hospital, University of Zurich


SCALES — Load ZGF/COPE/HAMD/PANSS/SSCL16/SANS questionnaire data

Loads ZGF, COPE, HAMD, PANSS, SSCL16, and SANS questionnaire data from standard files as generated by the internet-based "Zurich Questionnaire Forms", available for all the above instruments. Subsequently, syndrome scores are computed and optionally stored in databank. Specifically, Master.VOX supports syndrome-oriented approaches to psychopatholog which replace the mere yes-no dichotomy of diagnostic classification schemes by dimensional quantities and represent a valuable extension of operational criteria. Patients are described in terms of multidimensional feature vectors, thus avoiding the considerable loss of information inherent in diagnostic schemes. Syndrome-oriented approaches are well suited to resolve, for example, the fine gradations of within-pair concordance of monozygotic twins concordant and discordant for schizophrenia, or the mutual differences of intra-family psychic abnormalities that must not reach diagnostic significance.

            Specificationlist:      SCALES
            I4 INST                      0  Default-value
            I4 PROT                      0  Default-value
            I4 SAVE                      0  Default-value
            I4 LGIN              Undefined
            R4 PMAX                20.0000  Default-value
            01 INST Selects instrument to be processed
            02 PROT Controls printer output
            03 SAVE Controls storage in databank
            04 LGIN Logical unit number of input-device
            05 PMAX Maximum percentage of missing data that is permissible
            06 DEMO Examples that illustrate program function
            - INST = 0: Zurich Health Questionnaire ZGF
                        Sets VOX-Scales 1-5: sex,age,education,height,weight
                   = 1: Coping Strategies Inventory COPE
                   = 2: Hamilton Depression Scale HAMD
                   = 3: Positive and Negative Syndrome Scale PANSS
                   = 4: SADS Syndrome Check List SSCL16
                   = 5: SADS Syndrome Check List Supplement SSCL-SUPPL
                   = 6: Scale for the Assessment of Negative Symptoms SANS
            - PROT = 0: No print output
                   = 1: Detailed protocol
                   = 2: Mean values and standard deviations
            - SAVE = 0: Data are to be analyzed but not stored in databank
                   = 1: Data are stored in databank (existing data kept)
                   = 2: Data are stored in databank (existing data replaced)
            - LGIN = q: Logical unit number of input-device (standard=6;
                        valid numbers are 46-96)
            - PMAX = p: Maximum percentage of missing data that is permissible
            - DEMO: Familial Syndrome Patterns in Psychiatry


            &&START SCALES=Normative speech study zurich (study 600)
Fig. 11: Striking similarity between mean quantitative syndrome patterns derived by averaging across index cases (n=136; green bars) and mean quantitative syndrome patterns derived by averaging across "affected" first-degree relatives (n=116; red bars), as revealed through multivariate cluster analysis of SSCL16 syndrome scores.
Please note: (1) there are considerable inter-individual differences in the quantitative syndrome patterns within the population of index cases and the population of "affected" first-degree relatives; (2) within-family comparisons of syndrome demonstrate that the familial aggregation of psychopathology syndromes does not occur in a homotypic way, i.e., family data do not provide evidence for genetic segregation.

Everis, Spain
ETH, Switzerland
UZH, Switzerland
Freiburg, Germany
MA Systems, UK
Bristol, UK
Xiwrite, Italy
Ultrasis, UK
Jaume, Spain
Valencia, Spain
Lanzhou, China


EU-Grant (FP7):

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